Can You Mix Kratom With Marijuana? Is That A Safe Combination?

It has been a common practice by many users to mix various other drugs and herbs with Kratom to potentiate the effects of Kratom.

Potentiation of Kratom provides more strong effects.

People have been taking Kratom with Kava Kava.

Phenibut, Gabapentin, some opiates, and Cannabis. Mixing of Kratom and Marijuana is a common thing done by users.

However, is it safe to mix other drugs with Kratom? What effects or adverse effects does potentiation produce?

Marijuana and Kratom, is it a safe combination? Let’s look into the depth of this topic.

Kratom – The new sensation in recreational world

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If you take drugs and drink at parties, I am sure you must be aware of Kratom too.

So, basically, Kratom is a plant or a tree that is grown in various countries of Southeast Asia. The leaves of this tree contain alkaloids that produce some amazing effects.

The primary alkaloids are Mitragynine and 7-hydroxymitragynine. Kratom also has tryptamine alkaloids which are responsible for the psychedelic properties.

These alkaloids act on the Opiate receptors present in the brain to produce Opiate-like effects.

These effects include analgesia, stimulation, euphoria, relaxation, and sedation at high doses.

Effects of Kratom

Kratom produces various effects that include;

  • Stimulation: This effect is produced when the alkaloids present in Kratom acts on the Opiate receptors. Stimulation is produced at low doses.
  • Analgesia: This is achieved when the action of Kratom on Opiate receptors induce the release of enkephalins and endorphins and reduce the sensitivity of pain endings.
  • Euphoria: At low doses, the production of high feeling is due to release of serotonin and dopamine. The pleasure center of the brain is activated.
  • Relaxation: The phase of relaxation is proceeded by sedation if high doses of Kratom are taken.
  • Sedation: This effect is useful for those who are insomniac and suffer from other sleeping disorders.
  • Increased focus: Kratom enhances cognition and allows one to focus and concentrate better.

What is Marijuana?

Marijuana or Cannabis is the commonest used illicit drug. It is Schedule 1 controlled substance.

It is a psychoactive drug that affects almost all organs of the body.

It is also called weed, herb, grass, ganja, pot, Mary Jane etc.

The main psychoactive component of marijuana is delta-9-tetrahydrocannabinol (THC).

Other than this Marijuana plant consists of more than 500 chemicals including several cannabinoids.

Effects of Marijuana

After smoking weed or marijuana, THC is absorbed into the bloodstream and crosses the blood-brain barrier to reach the brain.

These cannabinoids then start affecting the memory, thinking, coordination and movement, time perception and pleasure.

THC and other cannabinoids affect the orbitofrontal cortex and hippocampus of the brain which is responsible for memory formation and attention.

THC is responsible for altering the functions of basal ganglia and cerebellum. Thus the reaction time is reduced and the posture loses balance.

THC is also responsible for inducing the release of dopamine that enhances the pleasure or reward center of the brain.

This is why people use weed for recreational purposes too.

Effects of cannabinoids also include a feeling of euphoria (high), relaxation, giddiness! The colors seem brighter and the emotions are profound.

Marijuana also has slight hallucinogenic effects and it also alters the mood. It increases heart rate causing tachycardia and palpitations.

It reduces blood pressure and the psychomotor coordination. It causes nausea and increases in appetite. The long-term effect is impairment in memory retrieval.

Hazards of Marijuana

  • Impairment of movement and coordination may lead to road traffic accidents if you are driving.
  • It may cause male sexual dysfunction and lower the sperm count.
  • The immune system is suppressed thus you may get frequent infections.
  • Long-term use can lead to the development of psychosis.
  • Risk of getting gum diseases increases.
  • Brain function is considerably reduced.
  • Acute memory loss
  • Causes testicular cancer in males
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Comparison of Kratom and Marijuana

Firstly, Kratom is legal in almost all parts of the world, while Marijuana is illegal. Secondly, Kratom produces milder effects while Marijuana produces quite strong effects. Thirdly, Marijuana is more sedative than Kratom.

Kratom and Marijuana combination

Kratom and Marijuana make a wonderful combination. To make this combination work, you can start by taking Kratom first and then after 1 to 2 hours you make take Marijuana.

Both drugs synergize the effects of each other. If both substances are taken in small doses one can achieve energy, positivity, and motivation.

Higher doses lead to sedation. Small doses keep one calm and less jittery.

If Kratom is taken in a small dose and Marijuana is taken in higher doses, Marijuana tends to mask the effects of Kratom.

Kratom is mildly sedative while Marijuana is highly sedative, so this dosage can result in dizziness and laziness.

Kratom and Marijuana both act as anxiolytics so they can be used as a combination therapy for anxiety.

Both drugs also have antidepressant action, thus it can reduce stress. Both drugs induce euphoria.

Must Read:  These Are The Best Kratom Strains For Treating Fibromyalgia

Both are sedatives so the combination can help those who suffer from sleep disorders especially insomnia.

Kratom and Marijuana for pain relief

The phytochemicals in Marijuana and Kratom are responsible for alleviating pain. The analgesic action of these two drugs is used for the following ailments;

  • Irritable Bowel Syndrome
  • Back pain
  • Knee and joint pain
  • Fibromyalgia
  • Neck stiffness
  • Traumas
  • Post-surgical pain
  • Mechanical injuries
  • Endometriosis
  • Multiple sclerosis

Pain management is achieved by the alkaloids present in Kratom that act on the mu and delta Opiate receptors to stop the transmission of pain signals.

Similarly, the alkaloids THC, CBD, and CBG present in marijuana help in pain suppression and increase the tolerance of body towards pain.

Medicinal benefits of Kratom and Marijuana

Common medicinal benefits of both Kratom and Marijuana include;

  • Analgesia
  • Muscle relaxation
  • Relief from stress
  • Anxiolytic action
  • Euphoria
  • Relief of insomnia
  • For chronic pain and illnesses like arthritis
  • Soothes nerves
  • Produces calmness of mind

How to take Kratom and Marijuana together?

Proper care is required while taking the combination. Both of these drugs have side effects so the dosage and method of consumption should be such that the adverse effects are kept minimal.

The dose of Marijuana should always be lesser than Kratom. Kratom can be taken in the form of powder, tea, with juice or even in the form of a capsule.

Once Kratom is taken wait for 30 minutes to 2 hours to smoke Marijuana. The concentration of both substances should be less to avoid the hyperactive behavior.

Side effects of Kratom and Marijuana combination

Some of the side effects associated with the consumption of Kratom and Marijuana mixture are;

  1. The feeling of being sick.
  2. Dizziness as both substances acts as sedatives at high doses.
  3. Paranoia reported by some users.
  4. Changes in tactile sensations
  5. Trippy feeling
  6. Vivid and bright visualizations
  7. Abdominal cramps
  8. Rush of emotions


Concluding, is it safe to take Kratom and Marijuana combination? Absolutely yes! Only if you know you are taking the right dose and you’re taking it at the right intervals.

There are no dangers of combining the two drugs in low doses. However, to remain on the safe side, ensure that you avoid taking highly sedative as well as energetic strains of Kratom.

Take milder strains of Kratom. With a white Borneo Kratom, you can take the sativa strain of Marijuana as it is more uplifting.

With a relaxing strain of Kratom like Red Bali, take the milder strain of Marijuana like Indica strains.

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