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Is Shilajit Safe to Take with Kratom? A Detailed Comparison

Kratom and shilajit. Two potent plant medicines are growing in popularity, but is it a match made in herbal heaven or a recipe for disaster? This is no boring compare and contrast. We are talking about firing up your energy, mood, and motivation with the power of nature’s bounty. But can you have too much of a good thing? This is a deep dive into the epic clash between these titans of traditional wellness.

We will uncover whether Shilajit’s mythical mojo amps up kratom’s oomph to eleven or drags it down to a crashing low. You’ll learn how to ride the razor’s edge to enhance kratom’s benefits and dodge dependence. We’ll tackle burning questions head-on: Can shilajit potentiate kratom? Does it lower tolerance? What about side effects?

By the end, you’ll know whether this stack packs a one-two punch or delivers a sucker punch to your health. Everything you need to harness these herbs’ hypnotic attraction while avoiding their hazardous traps. Let’s dig into this riveting ride at the intersection of ancient wisdom and modern biohacking!

An Introduction to Kratom

Kratom is derived from the leaves of the Mitragyna speciosa tree, which is native to Southeast Asia. The leaves are dried and ground into a fine powder. At low doses, kratom acts as a stimulant. At higher doses, it has sedative and pain-relieving effects.

Some of the significant alkaloids found in kratom include:

  • Mitragynine: This is the most abundant alkaloid found in kratom. It acts as a mild stimulant at lower doses. At higher doses, it has opioid-like effects.
  • 7-hydroxymitragynine: This alkaloid is produced when the body metabolizes mitragynine. It has potent analgesic and sedative effects.
  • Speciofoline, speciogynine, and paynantheine: These alkaloids contribute to kratom’s analgesic and sedative effects.

Kratom can produce effects similar to opioids, which is why it has become famous for chronic pain, anxiety, depression, and opioid withdrawal. However, it also carries a risk of dependence and side effects.

An Introduction to Shilajit

Shilajit is a thick, tar-like substance in the Himalayan and Tibetan mountains. It leaks from rock cracks in the summer and is collected for use in Ayurvedic medicine.

Shilajit is composed mainly of humic substances, including fulvic and humic acids. It is also rich in minerals, including iron, copper, zinc, magnesium, manganese, and phosphorus.

Some of the critical components of shilajit include:

  • This is the most abundant compound in Shilajit. It acts as a powerful antioxidant and mineral transporter.
  • These large organic acids are immune modulators and hormone balancers.
  • These compounds have cognitive and neuroprotective effects.
  • This compound is antifungal and antibacterial.
  • Plant sterols in shilajit can help reduce inflammation.

In Ayurveda, shilajit is used as a rejuvenator to boost energy, stamina, and overall health. It has antioxidant, anti-inflammatory, and immune-enhancing properties.

Comparing the Effects of Kratom and Shilajit

Kratom and shilajit produce some overlapping effects but also have many differences:


  • Kratom acts as a lower-dose stimulant by activating adrenergic and dopaminergic receptors.
  • Shilajit can mildly enhance energy levels by improving cellular metabolism and mitochondrial function.

Pain relief

  • Kratom has potent analgesic effects through its activity at opioid receptors.
  • Shilajit has modest pain-relieving properties from the dibenzo-α-pyrones and anti-inflammatory effects.

Mood enhancement

  • Kratom can lift the mood by stimulating dopamine and opioid signaling.
  • Shilajit may improve mood by reducing inflammation, balancing hormones, and increasing dopamine.


  • Kratom has strong sedative properties at higher doses, similar to opioids.
  • Shilajit does not have intrinsic sedative effects, although it can improve sleep by reducing stress.


  • Kratom carries a risk of dependence due to its activity at opioid receptors. Withdrawal side effects may occur if it is stopped suddenly after regular use.
  • Shilajit does not appear to cause dependence or withdrawal symptoms.

Side effects

  • Kratom may cause nausea, constipation, fatigue, and headaches, especially at higher doses.
  • Side effects are uncommon with shilajit. It is generally well tolerated, even at high dosages.

Analyzing the Safety of Using Kratom and Shilajit Together

Because kratom and shilajit have overlapping properties, there has been interest in using them together for enhanced benefits. But is it safe to combine these two supplements?

There is limited research on interactions between kratom and shilajit. However, based on their mechanisms of action and pharmacological properties, some potential synergies can be inferred:

  • Shilajit may prolong the effects of kratom by slowing its metabolism. This could increase the risk of side effects.
  • Shilajit’s minerals and fulvic acid may enhance the absorption of kratom. This could make its effects more potent.
  • Both supplements can raise dopamine levels in the brain. Used together, this could lead to overstimulation.
  • Shilajit may boost nitric oxide levels, which could worsen kratom’s blood pressure-lowering effects.
  • Shilajit’s stress and anxiety-reducing properties could compound sedation from higher doses of kratom.

Due to these possible interactions, caution should be used when combining kratom and shilajit. Start with very low doses of each and monitor the effects closely. Using higher doses together could lead to enhanced side effects.

People taking kratom to manage opioid withdrawal or pain should avoid combining it with shilajit, as this could slow the clearance of kratom and worsen dependence.

Additionally, anyone with heart disease, high blood pressure, diabetes, or taking medication should speak to their doctor before using kratom and shilajit together, as interactions could occur.

While kratom and shilajit may offer complementary benefits for energy, mood, inflammation, and immunity when used responsibly, enhancing proper precautions, the long-term safety of using them in combination still requires further research.

Shilajit as a Precursor for Kratom

One theory behind shilajit potentiating kratom relates to shilajit providing precursor compounds that increase kratom’s bioactivity. In particular, some claim that shilajit may act as a “kratom precursor”.

But what evidence is there to support this idea?

The Role of Dopamine

Shilajit has been shown in several studies to increase dopamine levels in the brain. One way it accomplishes this is by inhibiting the dopamine transporter (DAT).

DAT is responsible for the reuptake of dopamine from the synapses back into nerve cells. When DAT is blocked, more dopamine remains active in the brain.

Kratom also stimulates dopamine release. Therefore, shilajit’s effect on DAT may synergize with kratom to raise dopamine concentrations.

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The enhanced dopamine activity may lead to greater stimulation, mood enhancement, and possible potentiation of kratom.

Effects on Nitric Oxide

Another mechanism by which shilajit may enhance kratom is through increasing nitric oxide (NO) levels.

Shilajit has been found to boost NO production in the endothelium. NO causes vasodilation and helps regulate blood pressure.

By elevating NO, Shilajit may improve blood flow and nutrient delivery to the brain and other organs. This could increase the uptake and effects of compounds in kratom.

However, NO could also compound kratom’s blood pressure-lowering effects, increasing side effect risks.

Limitations of the Precursor Theory

While the mechanisms above may indicate some synergies, there are issues with labeling shilajit an outright “precursor” to kratom:

  • Shilajit does not contain kratom’s active alkaloids like mitragynine and 7-hydroxymitragynine.
  • It has not been shown to convert into any compound found in kratom directly.
  • Simply boosting dopamine or NO does not automatically potentiate kratom.

More clinical evidence is still needed to confirm whether shilajit definitively acts as a potentiator through direct precursor pathways.

Shilajit as a Kratom Potentiator

Beyond precursor theories, shilajit may strengthen kratom through other metabolic and pharmacological mechanisms:

Extending Half-Life

Some compounds in shilajit, such as fulvic acid, may slow down the metabolizing enzymes that break down kratom’s alkaloids.

A slower metabolism could extend kratom’s half-life. This means its active compounds remain in the bloodstream longer, making effects more drawn-out and potent.

However, a longer half-life also heightens toxicity risks and oversedation from elevated kratom levels.

Improving Bioavailability

In cell studies, fulvic acid has been found to enhance the transport of nutrients into cells. This may also apply to alkaloids and other active compounds from kratom.

Thanks to Shilajit, better absorption and bioavailability of kratom could logically lead to enhanced effects.

Modulating Opioid Receptors

Some research indicates humic and fulvic acids can interact with mu, kappa, and delta opioid receptors.

By modulating opioid receptors, shilajit may compound and alter kratom’s activity at these same receptor sites. This could amplify kratom’s pain-relieving and euphoric opioid properties.

Anti-Inflammatory Effects

Chronic inflammation is thought to dull sensitivity to opioids over time. The anti-inflammatory effects of compounds like benzoic acid and phytosterols in shilajit may help reduce inflammation-driven opioid tolerance.

Less tolerance could make kratom’s effects feel stronger. However, clinical evidence linking shilajit to reduced kratom tolerance is still lacking.

Kratom and Shilajit Combinations: Frequently Asked Questions

Is shilajit a potentiator for kratom?

Some anecdotal reports suggest shilajit can potentiate kratom, increasing its strength and prolonging its effects. This may be due to shilajit slowing the metabolism of kratom’s active compounds. However, clinical research has not confirmed whether shilajit definitively potentiates kratom.

Can shilajit reduce kratom tolerance?

Shilajit upregulates the production of several neurotransmitters, including dopamine and acetylcholine. This effect and its antioxidant activity may theoretically help lower kratom tolerance. However, no studies have evaluated shilajit for reducing kratom tolerance.

What’s the best way to take shilajit and kratom together?

The safest approach is to take regular doses of shilajit and kratom individually to assess tolerance. Once comfortable, low doses can be taken together, such as 250-500 mg of shilajit and 1-2 grams of kratom powder. Take on an empty stomach and monitor the effects closely.

Should you take shilajit and kratom at the same time?

It’s best to stagger them by 30-60 minutes. Take shilajit first, allowing it to absorb before ingesting kratom. This may help minimize interactions while still gaining complementary benefits.

Can you take shilajit daily with occasional kratom use?

Yes, shilajit can likely be taken daily as a general health supplement while using kratom occasionally. However, the safety of long-term concurrent use is unknown. Cycle kratom use and take regular breaks to reduce the likelihood of dependence.

Is shilajit safe to use with kratom for opioid withdrawal?

It’s best to avoid combining anything with kratom during opioid withdrawal, including shilajit. Kratom doses can be optimized individually to reduce withdrawal symptoms. Adding shilajit could prolong kratom’s effects and worsen withdrawal when stopping.

Can shilajit offset the side effects of kratom?

Shilajit may help reduce side effects like inflammation, headaches, nausea, and constipation through its anti-inflammatory, antioxidant, and gut-regulating properties. However, it could worsen other side effects like sedation and low blood pressure.

Will Shilajit show up on a drug test for kratom?

No, shilajit will not cause a positive drug test for kratom or opiates. Kratom alkaloids are the only substances that would be detected on a kratom drug test. Shilajit does not contain mitragynine, 7-hydroxymitragynine, or other compounds screened for in kratom testing.

Can shilajit be used to help with kratom withdrawal?

Shilajit is not clinically proven for kratom withdrawal. However, its anti-inflammatory, antioxidant, and neurotransmitter effects could hypothetically help ease withdrawal symptoms like anxiety, low energy, and muscle aches. More research is needed to evaluate Shilajit’s role.


The votes are in. While kratom and shilajit both offer temptation with their powers, combining them is a union laced with risk. Like adrenaline junkies chasing the ultimate high, some may thrive on hiking up the synergy of stimulation, pain relief, and mood elevation these two can fuel. But playing with fire often ends in ashes, and overdoing this stack may leave you crashed out, dependent, and dodging dangerous side effects. Respect the nuanced dance between dosage, products, and personal biology.

A seasoned biohacker may unlock euphoric creativity and vitality with prudence and awareness. But the novice drawn to shortcuts would be wise to resist the reckless allure of more, more, more.

Mature, responsible use can allow you to drink sensibly from the fountain of youth in these ancient herb springs. Yet it’s best to remain sober about the limitations of current understanding. There is still much to be revealed in the ever-unfolding mystery of how these robust plants interact within our body, mind and soul. Until science catches up, tread carefully upon the razor’s edge between awakening and oblivion, balance and excess, synergistic harmony and hazardous discord.

Christina Earle
Christina Earle is a licensed psychologist practicing in Oakland, California since 1999. She provides counseling to people who are struggling with managing stress, and anxiety related issues. In her free time, she often writes on mental health conditions that educate the individuals to explore ways of improving their health.

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