Etizolam is one of the commonly available drugs for depression and anxiety. It has a similar effect as that of benzodiazepines i.e. Onfi, Tranxene, Xanax, etc.
The difference between two is that benzodiazepines need a prescription for purchase whereas Etizolam is available over the counter.
It helps in stress release. It often causes a sedation and mild euphoria. It is very much sensitive as per dosage. It is readily available from local pharmacies.
The safe usage suggests it with optimum dosage. A higher dose has a comparatively serious health risks. More details on its safe usage are as follows.
What is Etizolam used for?
Etizolam is an anxiolytic, sedative-hypnotic, and antidepressant medications.
It is available under multiple brand names such as Etilaam, Sylazepam, Depas, Etizola, Etizest, Mozun, Nonnerv, Pasadena and Sedekopan.
It is an oral therapeutic medicine for adults which suffer from the medical conditions of stress, anxiety, and convulsions.
It is also sometimes a useful therapy for the treatment of insomnia as it relaxes the mind and induces sleep.
It is helpful for several situational, psychological conditions such as panic attacks, secondary psycho-somatic diseases and much more.
Pharmacokinetics of Etizolam
Being a derivative of thieno-diazepine, etizolam has a faster absorption system. The best of its effects are between 25 to 30 minutes of taking the dose.
The maximum time to wait for the results is up to two hours. If the results aren’t showing up, the user may need to repeat the dose or change the dose.
Etizolam is a hypotonic compound. It follows the mechanism of action by attaching to the benzodiazepine receptor.
It acts as a full agonist for this particular function which further ensures best therapeutic benefits to show up.
It is safer than similar compounds as it has a little risk of accumulation even after a long-term use. It helps to relax the nerves, initiate sedation and eventually makes the user fall to sleep.
How does Etizolam work?
The working of Etizolam applied through the inhibitory GABA neurotransmission. The thing which differentiates Etizolam and other benzodiazepine is that Etizolam is comparatively more precise.
Also, its affinity is so much higher for binding to the A2 subunit of postsynaptic GABA receptor subtype.
This affinity and eventually activation ends up producing a stress relief effect. However, the potential to cause a bounce back anxiety from a drug withdrawal.
It is mostly because the regulation of A2 subunit is not possible by Etizolam as other benzodiazepine derivatives do.
Etizolam has the powerful relaxing effect which is one of the reasons to get the relaxation. It also has links with increasing intra-synaptic concentrations of neurotransmitters, serotonin, and norepinephrine.
That is the reason why Etizolam has other anti-depressant properties. All these factors suggest that why is Etizolam a necessary medicine for multiple disorders and psychological conditions.
How to take Etizolam?
Etizolam is over the counter available, but for safe dose, the recommendation from a doctor is better.
A doctor can suggest the most useful treatment for the respective user by age, weight, requirement and the health condition. Following a routine on a daily basis makes it work better.
How much is Etizolam sufficient?
The ideal dosage needs administration by the doctor. A maximum dose which can help for a user is 3 mg which no one should exceed.
- Anxiety: Only 0.25 to 0.5 mg twice a day works well for stress and anxiety.
- Panic disorders: For panic attack and related disorders, 0.5 mg twice a day is helpful.
- Insomnia: For sleep regulation and insomnia, 1-2 mg of Etizolam daily is sufficient.
The tablet of Etizolam is available in various strengths. It includes 0.25 mg, 0.5mg, 1 mg and 1 mg. A user can select any tablet strength as per requirement.
The dosage info acquired from PubMed.gov.
The short and long-term use
Usually, doctors prescribe Etizolam for a maximum of 12 weeks. The regularity of dosage is necessary as it may disrupt the benefits if a user leaves it half way.
For this reason, the use of Etizolam should not halt at once. Instead, the correct idea is to reduce the dose gradually. Lessening the risk of unwanted effects is important.
If someone misses a regular dose, the best technique is to keep on following the routine after skipping the missed dose.
There is no need to double the next dose after the missed dose. It can produce a highly undesirable overdosing effect.
Storage instructions for Etizolam
The chemical composition of Etizolam is safe at room temperature which is between 20 – 25°C.
The general precautions include protection from heat, moisture and direct sunlight which may change the chemical structure of the compound. The original packing has an expiry date which is a must check before purchase.
It is not safe for the underage people, children and those who are suffering from a medical condition.
If not in use, the leftover tablets should not be discarded into sewage water. The disposal needs a correct method to follow which only a certified doctor or pharmacist can explain.
Is Etizolam safe to use?
Like all chemical-based medicines, Etizolam has certain limitations when it comes to safe usage. Almost all medications require care in dosage design.
With Etizolam, least is the better. It is only available in smaller strength in the market. Although it is an over the counter drug, the safety measures apply to it at large.
It is only safe to use when the user is consuming the right amount of its formula. In a lower or higher dose, it is not helpful.
In a case of low dose, the user may not get the desirable effects i.e. stress relief. Whereas in a case of high dose, it may cause extremely uncomfortable health effects.
Either way, it’s a not a sound idea to experiment with Etizolam dosage. It suggests that the safety of using Etizolam is dependent on fair use only.
Interactions and Warnings
The oral medication of Etizolam needs a background study of the health condition and requirement.
The doctor should know the previous and current health status along with the body proportions and daily drugs if any.
- Medicines: If the user is already on a medication such as fluvoxamine and carbamazepine, it may increase the risk of the interaction with Etizolam.
- Alcohol: The regular alcohol users may need to leave alcohol before using Etizolam. During medicine, using alcohol is highly dangerous.
- Physical activities: Any physical activity such as driving which needs mental and bodily concentration may affect from Etizolam. The effect of Etizolam may impair the vision and the motor skills. That is for personal safety to value such factors.
- Pregnancy and breastfeeding: The effects of Etizolam may hinder with the health status of pregnant and lactating mothers. In such condition, the consent of doctor is necessary to get a safe dosage determination.
- Allergy and sensitivity: For those who are sensitivity to Etizolam and similar benzodiazepine may need to tell this to their doctor before consuming it. Using Etizolam for such people may trigger an allergic reaction.
- Overdosing effects of Etizolam: The Etizolam has shown an overdosing force in high amounts.
In the case of experiencing such effects, one should immediately stop the usage of Etizolam. The user needs to consult the local health service provider as soon as possible.
Side effects of Etizolam
The ultimate effects of Etizolam can occur as a singular or a combination of many. Some of them are as follows.
- Slow heartbeat
- Slurred speech
- Visual impairment
- Nausea and vomiting
- Dry mouth
- Excessive saliva
- Urinary tract infections
- GI problems
- Decrease in libido
- Weakness of muscles
- Loss of appetite
- Respiratory problems
All these effects may show up at any stage. The chances of getting two or more effects altogether are also common.
These effects are not the same. There may be similar conditions which are not a part of this list. The experience of any of these symptoms needs an immediate consultation from the doctor.
Legal status of Etizolam
Etizolam has different legal status in many parts of the world. In Denmark, it comes under Danish Misuse of Drugs Act. In Germany, Etizolam was controlled in 2013.
In Japan and the United Kingdom, it was restricted. The government of UK classified Etizolam to be a Class C drug which is after amendment in the Abuse of Drugs Act of 1971.
The Food and Drug Authority, FDA in the USA has not authorized Etizolam for safe use. However, it is legal for research purpose.
Final thoughts on safe use of Etizolam
Etizolam is a common generic name for a medicine which provides relief in stress, anxiety and other related problems.
It often becomes questionable for its legal status and safe use. Many of the researchers and users believe that it has more damaging effects than benefits.
However, the dosage sensitivity and risks with overdosing suggest the need of careful dosage design.
For anyone suffering from a medical condition of anxiety, Etizolam is more than helpful. Only it requires proper administration using does design and adjustment.