What is Moringa Oleifera? Benefits, Side-Effects, and Dosage

Moringa Oleifera, more commonly known as the Horseradish tree or the Ben Oil Tree has been famous for its nutritional content since Medieval times. It has now only recently made its mark in the modern health market as a herbal supplement and a super food, capable of many deeds. It reaches up to the height of 10-12 m, has fragrant flowers and a three-sided brown capsule fruit.

Moringa originated in and is mainly cultivated in India, Pakistan, Asia Minor, Africa (Used widely in African Folk Medicine) and Arabia. It can be grown as crops, in the wild or as a solitary tree grown in home gardens.

In 2008, the National Institute of Health labeled Moringa as ‘The plant of the year’ due to its highly lauded medicinal benefits.

What is Moringa?

A profiling done of the Moringa plant shows that it contains protein, vitamins, beta-carotene, amino acids, phenolics and rare combinations of zeatin, quercetin, beta-sitosterol, caffeoylquinic acid, and kaempferol.

Research has demonstrated that every part of this tree, such as the leaves, flowers, saps, seeds, bark and roots, can be used in a way to derive maximal nutritional factors. This plant has proved to alleviate problems in third world countries due to its drought resistant properties.

Medicinal and pharmacological benefits of Moringa:

Moringa is being used to relieve different ailments and has shown promising results in the field of medicine. Its star properties include; being used as a cardiac and circulatory stimulant, having antitumor, antipyretic, anti-inflammatory, antiulcer, antispasmodic, diuretic, antihypertensive and cholesterol reducing, and fighting against different bacterium and fungi.

Literature review and numerous publications have highlighted some of the esteemed benefits of Moringa which are listed as follows:

  • Role in brain health

Moringa being a rich source of the essential amino acid tryptophan and neurotransmitter serotonin has shown improved levels of the ‘feel good’ by elevating mood levels and depression.

Due to these findings, Moringa has shown promising results in alleviating anxiety and depression, even while being used in the powdered form.

A special extract of Moringa tested on mice has shown anti-amnesia effects and improved learning [5].

  • Antiinflammatory and antioxidant properties

Moringa contains constituents comparable to anti-inflammatory compounds such as carotenoids and essential amino acids, and oxidative stress fighting elements such as beta-carotene, Vitamin C, and Quercetin, which has been seen to battle against chronic diseases.

It has seen to possess characteristics similar to Indomethacin used for chronic gout.

  • Antibacterial, antiviral and antifungal properties

Moringa roots are seen to have a protective antibacterial effect. They are seen to be comparable to the antibiotic Tetracycline [3].

The bark also shows anti fungal effects, while the juice from the bark showed protected effects against Staphylococcus aureus and Pseudomonas aerogenous. Moringa also demonstrates effect against Hepatitis B (HBV).

  • Antispasmodic and antiulcer properties

Moringa roots inhibit spasmodic action by calcium channel blockade due to which it has proved to be beneficial in treating diarrhea, gastric motility disorder, and irritable bowel syndrome. The methanol fraction of this plant has demonstrated substantial anti-ulcer and hepatoprotective effects.

  • Anti-hypertensive, diuretic, and cholesterol lowering properties

Moringa leaf extracts have been known to encourage cardiovascular health by reducing cholesterol levels. The blood pressure lowering effect work possible through the mechanism of calcium antagonist effect, vasodilation and increased antioxidant potential.

  • Interactions with glucose metabolism

The chlorogenic acid derived from Moringa has shown promising results in reducing blood sugar and allowing cells to independently take up and release sugar which ensures moringa to possess natural protection against diabetes. Experimental trials have shown reduced markers of diabetes ( IgG, IgA, and HbaA1c) in subjects who were given Moringa.

  • Anti-tumor and anticancer activities

Very significant anti-carcinogenic effects of Moringa have been seen in the inhibition of Epstein-Barr Virus and early antigen which has been seen to reduce cases of Burkitt’s Lymphoma.

It has also shown the capability of having protective potential against hepatic carcinogen metabolizing enzymes.

There is also evidence of protective effects against melanoma, pancreatic cancer, colon cancer and cervical cancer.

  • Regulates hormones and slows down aging

Moringa has been used as a superfood to improve levels of antioxidants, serum retinol, serum ascorbic acid, glutathione peroxidase, superoxide dismutase and selenium which in turn slows down effects of aging and senility.

Moringa has also shown to decrease conversion of circulating T4 into T3, thus regulating thyroid function.

It has also been used as a natural aphrodisiac since medieval times to improve sexual libido and erectile dysfunctioning in males and to prolong sexual activity in females.

  • Aesthetic properties

Topical application of Moringa on the skin every morning has shown wound healing properties due to fibrinolytic and fibrinogenolytic effects.

High hydration of skin also observed due to Moringa which leads to increased smoothness and color consistency of skin and reduced appearance of wrinkles.

How to use Moringa?

Dosage: Standard dosages are set at 150-200 mg/kg oral intake. According to its set standard, doses according to weight of a person have been set as follows:

  1. 1,600-2,200 mg for a 150lb person
  2. 2,100-2,900 mg for a 200lb person
  3. 2,700-3,600 mg for a 250lb person

Safety and efficacy

Now even though this drug is thought to be non-toxic, that might not be the case. Supplemental dosages have been listed below and a 3-4 times increase in dosage might produce genotoxic damage and may pose to be carcinogenic.

The high dose is thought to be optimal and possess greater potency than upper and lower doses. At higher doses, much of the anti-oxidant properties are wasted.

Its efficacy can be improved by pairing it with Oranges (Citrus Sinensis) to suppress the formation of ulcers in the chronic inflammatory disease Ulcerative Colitis.

Side effects of Moringa

  • Moringa is known to be genotoxic (overdosing only) causing genetic damage, and target organ damage in the Liver and Kidney.
  • It has been shown to induce abortions in pregnant rats, although human experiments have not yet been conducted. Due to which its usage as an early galactagogue supplementation has been questioned.
  • Moringa is also suspected to have anti-fertility properties in females at higher dosages. It can also be availed for contraception purposes.
  • It has also demonstrated anticoagulant properties, although the dose at which this effect occurs is still unclear.

Contraindications: Please consult your doctor if pregnant or breastfeeding.

User reviews of Moringa

Users dosing on half to 3 teaspoons of the dried powdered form of Moringa have reported a grassy, spicy/ pungent taste similar to radishes.

Users with chronic inflammatory illnesses have reported a subsequent reduction in ‘feeling inflamed and allergic.’

Obese patients have reported a significant healthy weight loss and better and large bowel movements.

Healthy people with normal BMI and eating habits have said better-formed stools and digestion without any signs of urgency.

Users using Moringa as a component in detox drinks and smoothies have reported high levels of energy, better mood, and clarity of mind.

The same mental and emotional effects have also been described by patients suffering from chronic inflammatory diseases.

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