Tianeptine is a water-soluble nootropic used for its antidepressant and anxiolytic qualities. The French Society for Medical Research discovered and patented Tianeptine in the 1960s, and it is listed as an antidepressant selective serotonin reuptake enhancer (SSRE).
Clinical research shows that Tianeptine is one of the most effective treatments for mild to severe major depressive episodes, such as anxiety disorders (to include panic disorders), severe depression and bipolar disorder.
Tianeptine is also sold under brand names Stablon, Tianeurax, Coaxial, and Tatinol.
Tianeptine mechanism of action
The first few clinical studies published on Tianeptine indicated that its mechanisms of action and its effectiveness could be traced back to its properties as a serotonin reuptake enhancer. Serotonin is a neurotransmitter that relays chemicals in the brain.
These chemicals in the brain are what is at the root of our feelings of happiness and well-being, and it is also responsible for the modulation of sleep and appetite.
Tianeptine’s efficacy is related to this process has been debunked by current clinical studies that used more powerful technology to deliver more accurate results.
Research now shows that Tianeptine indirectly alters AMPA and NMDA receptor activity and produce better receptor activity.
These two receptors are part of two major groups of receptors that are involved in one of the brain’s different excitatory processes.
These excitatory processes have potential to enhance alertness, attention, learning, memory, and speed of reasoning, but can also cause nervousness and anxiety if overstimulated.
The second process listed here is at the heart of the compound’s mood-boosting abilities. Further explanation of the nootropic property of Tianeptine is how it changes neuroplasticity and causes the secretion of brain-derived (BDNF), a neurotrophic factor and protein.
This protein helps neurons proliferate and survive when it is released in the brain.
Medical uses of Tianeptine
Tianeptine has been used as an off-label nootropic agent to treat mild to major depression in France and other European countries.
Research has shown that Tianeptine is just as effective against major depression as anti-depressant pharmaceuticals, such as imipramine amitriptyline, and fluoxetine, but without the associated side effects and risks of addiction.
It was shown to be more efficient than maprotiline in a group who had co-existing depression and anxiety disorders.
Coincidentally, Tianeptine has been found useful in treating other medical illness, and it has shown promise in successfully treating irritable bowel syndrome (IBS) on a level with another pharmaceutical that is currently used amitriptyline.
Clinical trial results put Tianeptine on par with the effectiveness of amitriptyline, which is frequently used to treat uncontrollable pain and cramping in IBS sufferers.
However, the use of Tianeptine doesn’t cause the adverse side effects associated with amitriptyline.
Other medical uses for Tianeptine include the treatment of asthma, ADHD, post-traumatic stress disorder and erectile dysfunction.
The main benefits that Tianeptine offers are of its effectiveness in alleviating anxiety and mood disorders.
Individuals that suffer from these disorders taking Tianeptine can also expect an improvement in their cognitive abilities.
Another great benefit is that the compound has anxiety-inhibiting effects that do not negatively impact acetylcholine or cardiovascular function.
This makes it a good candidate for the treatment of the elderly and individuals recovering from alcoholism that may be sensitive to the treatment with current anti-anxiety and antidepressant medications currently on the market.
Tianeptine is also an effective analgesic for individuals suffering from chronic pain and has exhibited benefits as an effective painkiller in the treatment of disorders such as fibromyalgia. It also shows benefits in treating intestinal health issues.
1. Sensory Perception
Clinical studies on rats conducted at John Hopkins Medical indicated that selective serotonin reuptake inhibitors (SSRIs) like Tianeptine caused an increase in density of nerve-impulse-carrying axons in the areas of their brain which control the sense of smell in rats.
Researchers postulated that BDNF was behind the change because it causes serotonin axon growth. First-time users of Tianeptine may experience a heightened sense of smell because of these effects.
2. Memory and Learning
Tianeptine is an effective nootropic agent because it reduces mental and physical stress on the brain.
As it lessens this stress, users will begin to experience better brain cognition and memory and also improved learning — both conditions that are diminished by major depressive disorders.
3. Energy, Mood, and Motivation
Tianeptine is reported to produce mood-brightening effects, such as a sense of well-being and mental clarity and optimization.
Tianeptine safety, tolerance and drug interactions
Many antidepressants on the market today have adverse side effects and risk for addiction. Tianeptine is a safer alternative to these drugs and also carries no risk of dependency.
There are fewer adverse side effects, and those associated with its use are minor.
Complaints included drowsiness, dry mouth, dizziness, insomnia, vivid dreams, constipation, and low blood pressure.
It is important to consult with your doctor regarding all drug interactions, safety, and tolerances you experience while taking Tianeptine.
It is known; however, that you should especially take caution when using monoamine oxidase inhibitors (MAOIs) with Tianeptine.
A MAOI should not be taken 14 days or less in conjunction with Tianeptine because severe and even fatal medical complications can happen if you do.
Tianeptine dosage information
Pill forms of Tianeptine mostly come in 12.5 mg formulations. The suggested dosage is to take a single pill or tablet three times per day. It is best to divide up the dose up to ensure the body metabolizes a steady supply of the drug.
It is recommended that those new to taking it start out with a smaller dose, such as cutting the pill in half to take once in the morning and again at night. Only increase your dosage level once you have become accustomed to its effects.
It is important to use this Tianeptine while consulting with a qualified physician who knows your medical history and can guide you through its use. Tianeptine users should also consult with their physician when they stop taking it.
Some stacks may potentiate Tianeptine, especially those with anti-depressive properties that have a similar chemical makeup.
It is suggested to try a stack approach with a mild or vegetable-based nootropic, such as artichoke extract.
Artichoke extract can have a powerful effect on memory and cognitive performance, so it can enhance your experience while nurturing your brain.