Kratom is a natural stimulant that comes from the leaves of a tropical tree grown in countries like Indonesia, Malaysia, and Thailand. The leaves of this tree come in three types of variety or central vein i.e. red, white and green.
The alkaloids present in the leaves of this tree are mainly mitragynine and 7-hydroxymitragynine. These alkaloids show agonism towards the opioid receptors present within the central nervous system.
At low doses, the effects produced are more cocaine-like while at high doses calming effects are produced that includes sedation.
The leaves used in the form of powder, capsules, tinctures, extracts, and tea. You can also smoke or chew the dried leaves.
The pharmacokinetics of Kratom not fully understood due to lack of proper research, but this article will enlighten Kratom users about the onset of action, duration of action and pharmacodynamics of Kratom. It will also focus on how long does Kratom stay in your system, and what promotes it absorption and excretion.
Pharmacokinetics of Mitragyna Speciosa
The pharmacokinetics of Kratom is necessary to figure out its potency as well as efficacy. How well does Kratom absorb, how long does it stay in our system, what increases its excretion and what potentiates its effects, these all are studied under pharmacokinetics.
Absorption of Kratom
Kratom absorption increased if it consumed in the form of powder. If it took in the shape of capsules, the absorption delayed. To increase the consumption of Kratom, it is taken with grapefruit juice or made in the form of tea. Absorption also increased if it is taken on an empty stomach at least 45 minutes before the meal.
Onset of Action
The beginning of action occurs 5-15 minutes later after burning Kratom. That can increase if the absorption increased. The onset can also increase if Kratom placed sublingually, but due to its bitter taste people usually, follow the toss and wash method.
Duration of Action
The duration of action of Kratom is different for various types of Kratom. Duration of action is also synonymous with the half-life of Kratom. The half-life of Kratom is four to six hours. Some kratom strains have a longer duration of action, and these strains are more relaxing. The stimulating strains usually have a shorter duration of action.
A study was conducted by a group of scientists. The target of the study was a group of males who had been abusing Kratom since two years. The outcomes of the survey recommended that the elimination half-life of mitragynine is around 23-24 hours (+/- 16.07 hours).
The interpretation means that around 50% of Kratom will be excreted/eliminated from the body in almost one day. That means that to have 0% Kratom in the body, a person has to wait 5-6 days after consumption.
So here we get the answer to our question that how long Kratom stays in our body.
Those who have a fast metabolism, they remove Kratom quickly from their bodies, and it only takes 7.17 hours.
Slow metabolizers, on the other hand, have an elimination half-life of 39.31 hours, so Kratom stays in their bodies for around nine days.
Pharmacodynamics of Mitragyna Speciosa
The mechanism of action of mitragynine and 7-hydroxymitragynine is that it acts on the opioid receptors present in the CNS. At small doses, the action is primarily on kappa receptors and at high doses the action shifts to mu receptors.
Mitragynine is an agonist at these receptors. A decision on these receptors induces the release of enkephalins that help in suppressing pain and endorphins that reduce stress levels and makes one euphoric. Kratom also promotes sympathetic activity.
Can Kratom be detected in urine? If yes, for how long?
As it has stated earlier that Kratom has an elimination half-life of 1 day and requires a minimum of 5-6 days to be completely removed from the body. Thus it can easily be detected in urine. However the excreted content is not usually Kratom, it is the metabolic product of Kratom that detected in urine.
What are the variables that influence the stay of Kratom in one’s body?
- The greater amount of Kratom you take, the longer it stays. The more concentrated specimen you take, the longer it stays as it depends on the content of mitragynine and other alkaloids.
- Elderly persons take a longer time to eliminate Kratom from the system.
- More intake of water reduces elimination half-life of Kratom as the urinary output increases.
- Obesity allows one to keep mitragynine for longer periods of time as it is lipophilic.
- If you take more fats in your diet, then the absorption of Kratom is increased, and thus it is quickly metabolized and rapidly eliminated.
- Any disorders of liver and kidney increase the duration of Kratom staying in the body.
- Higher basal metabolic rates promote quick excretion.
- The more you consume Kratom, the lesser is the elimination of Kratom.
How to clear Kratom from your system?
The best way to remove Kratom from your body is to take as much water as you can. The more your urinary output rate is, the quicker you are going to get rid of Kratom metabolites from your body. Also, go for exercises and run. When you sweat you lose the metabolites of Kratom, plus you’re wasting fat stores.
Kratom tends to accumulate in the fat stores of our body. To remove Kratom from the digestive tract, try using charcoal. Activated charcoal adsorbs Kratom.
Along with this, the intake of acidic food, drinks, and beverages increases elimination of Kratom by acidifying the pH of blood and degrading the labile acid alkaloids of Kratom. The use of Calcium-D-Glucarate also improves the excretion of Kratom from the body.
It is important that when you aim to remove your system from Kratom, you do not consume it.