The popularity of Kratom has no boundaries. The users belonging to varied age groups and a diverse ethnicity. The question if Kratom works for everyone has an only one-word answer. Yes, it works for everyone, but the working may differ by various factors.

One such factor that differentiates the use of Kratom is “sex” of the user. Kratom may work differently for men and women, and it is no more a mystery. Being a powerful herb, Kratom is highly dosage dependent. That is why Kratom sometimes act differently for both sexes, as per dosage and effects.

This makes Kratom a different herb responsible for multiple functions in men and women.

Why May Kratom Work Differently In People?

The magic herb from Southeast Asia, Kratom is making headlines for its health effects. It was first noticed in 1834 in Malaysia.

All these effects are due to the chemical compounds called “alkaloids” of Kratom. These alkaloids are bioactive compounds, which give unique properties to the plant.

Leaves have the maximum amount of these alkaloids that is why traditional usage of Kratom involved chewing leaves mainly. They are also present in other parts of the plants, but they are not as much as in leaves.

An assessment study on Kratom alkaloids tells that Kratom leaves have 0.5 to 1.5% of alkaloids in it. Mitragynine is the significant part of alkaloid list. But the distribution and quantities of these alkaloids vary by geographic regions, seasons, extraction methods and strain.

Considering the most potent Kratom alkaloids, 7-hydroxymitragynine, which is assumed to be 30 times stronger than Mitragynine. It is so strong that it works better than morphine.

The concentration of alkaloids varied in each strain. The red vein Kratom leaves have high sedative powers, and thus they have the high amount of Mitraphyllineand 7-hydroxymitragynine level in them.

On the other side, the stimulatory powers of green and white vein leaves are due to heavy Mitragynine and lower 7-hydroxymitragynine content. Some other alkaloids responsible for incredible Kratom effects are as follows:

  • Ajmalicine; An antiaggregant, anti-adrenergic, sedative, muscle relaxant, and anticoagulant.
  • Ciliaphylline: Shows the analgesic effect.
  • Corynantheidine: Is an opioid antagonist.
  • Corynoxeine: Is a calcium channel blocker.
  • Corynoxine: Has dopamine facilitating the anti-locomotive impact.
  • Epicatechin: Is an antioxidant that has anti-diabetic, anti-hepatic, anti-inflammatory, anti-microbial, anti-cancer properties.
  • 7hydroxymitragynine: Is an analgesic and has anti-diarrheal, and an antitussive effect.
  • Iso mitraphylline: Is an immunostimulant and as the anti-leukemic effect.
  • Mitragynine: Causes analgesia, anti-diarrheal, anti-malarial effects and is a psychedelic antagonist.
  • Mitraphylline: Acts as a vasodilator, muscle relaxant, diuretic and immunity enhancer.
  • Paynantheine: Helps to relax smooth muscle.
  • Rhynchophylline: Acts as a vasodilator, calcium channel blocker, and a hypertensive.
  • Speciogynine: Helps to relax smooth muscle.
  • Speciophylline: Has an anti-cancer effect.
  • Tetrahydroalstonine: Has an anti-adrenergic and a hypoglycemic effect.

Are Kratom Effects Same For Men And Women?

Based on general assumptions and user experiences, Kratom works differently on men and women. The overall effects of Kratom are same on both of them, but the intensity, duration, and visibility of these effects may vary.

The effects of Kratom show up as a pleasing phase that makes a user happy, reduces stress, pain, cause peace of mind and makes him energetic.

Kratom is a life changer for people but how would it mainly help considers the factors such as sex, age, previous experience, dose, choice of strain, the method of use, etc.

Considering the difference of effects in men and women, the efficacy is even supported by research. There is no as such research on Kratom impact on men and women to differentiate, but there are similar studies as per certain medications.

The scientists believe that the efficacy of the medicines depends more on sex and less on the dose. The reason why it happens has answers in hormones and genes of men and women.

The body’s mechanism of metabolizing drugs is different. It applies to herbal medicines, i.e., Kratom as well.

It is normal to see that women are rarely a part of a clinical trial of medicine. Because there is this assumption of what will work for men will work for women.

The majority of research is done with the assumption that men and women are biologically the same, which is not technically correct. It shows that effect of Kratom is also common in both sexes however it may appear differently.

A Kratom user named Jennifer Miller shares her Kratom experience on Youtube. She had a back injury and was unable to walk, sit, stand, or lay down for more than 20-30minutes at a time. It was so difficult for her to even sleep after the injury. Her coccyx and tailbone were severely damaged. Jennifer was prescribed with an opiate cocktail (400mg daily) of fentanyl patches, Opana, & Roxicontins.

After some time, it didn’t seem like working on her, and she was emotionally disturbed. She tried to switch to herbal remedies and started using poppy tea. Later on, Jennifer read about Kratom online. She asked her doctor about it, and he allowed her to use Kratom.

Surprisingly, the first dose of Kratom made her pain free in 45 minutes. She was able to walk without assistance. Jennifer found Kratom to be a perfect replacement for her opiates, an ideal mood enhancer, and stress reliever.

The reason why women have different effects is that they have different hormones, body composition, and metabolism. Women are traditionally protected against cardiovascular diseases when compared to men. But it is challenging to predate the effects in a transsexual woman.

For Kratom, the differential effects in women can be of two types.

1) By Means Of Dosage

For women, it takes comparatively less dosage to work. A little dose, i.e., 0.5g to the 1.0g grams in women would function same as that of 2.0 grams to 3.0 grams in men. [ref]

All the general guidelines on Kratom mostly involve male users. The standard dosage is what works best for men. There is never any specific guideline on dosage concerning women.

The reason is, it is clear that Kratom effects show up on both men and women. But how much Kratom dosage helps is not a fixed standard. Even in men, different dosage works on different individuals. When there are only men, the analysis is based on age, health status, medical conditions and previous usage of Kratom strains.

When it comes to women, this differentiation of effects also includes factor sex. Also, they have extra body fat compared to men. Most of the stress relieving medicines that are fat-soluble will act differently in women. That is why the antidepressants work better in women.

For women, more is not better. The best dose of Kratom is the one that brings the maximum benefits.

The user has to experiment and determine the perfect level of Kratom all by herself. The body reaction of every person varies. Some of the factors that contribute to Kratom dosage determination are as follows.

  • Quality of Kratom (The best-graded Kratom brings maximum effects)
  • Time to take Kratom (usually it works best on an empty stomach)
  • Body weight (heavy body weight women need more dose)
  • Amount of Kratom that you use (if you have already taken Kratom on the same day, the second dosage will require a higher quantity of work)
  • Taking any other medicine with Kratom (It is strictly not recommended)

2) By Means Of Effects

While using Kratom, women experience the same impact as men. The only difference is in the intensity of these effects. The difference in dosage brings the results early in women.

Male users may take a little longer time to exhibit the impact. Meanwhile, the effect on low dosage is very well defined, evident and concise in females.

The intensity of the effects is ideally what a user gets typically with a standard dose of 3g to 5g. Stimulation, energetic boost, mood enhancement, happiness, nootropic assistance and all these effects show up on the minimum dose.

Only the higher effects such as stress relief, pain relief, and euphoria are not standard on a low dose. But increasing the low dose to moderate will enable the female Kratom users to enjoy all these effects.

Best Effects Of Kratom In Women

Kratom brings the following beneficial effects in women.

  • It improves the mood.
  • It reduces stress.
  • It energizes the user.
  • It is a good painkiller.
  • It regulates the sleep cycle.
  • It relieves PMS symptoms.
  • It relieves menopause symptoms.
  • It increases libido.

What Are Users Saying About It?

Cheryl Bailey, a Kratom user, narrates her experience that she was diagnosed with a rare congenital disability. After several surgeries to heal it, she was in severe pain. The prescribed medicines to her made her life hard after prolonged use.

In 2015 she discovered Kratom, and it has helped her to leave using medications. She says that Kratom has saved her life and she is now leading a pain-free and opiate-free life.

Another Kratom user, Jasmine, a professional pianist and piano teacher shares her experience. After 17 years of playing piano, she started feeling pain in her knuckles and hands. The doctor prescribed her over the counter pain killing medication. After a particular time, she decided to switch to herbal remedies for which Kratom helped without creating a side effect.

Can Women Get Any Side Effect From Kratom?

Kratom is safe for health. There are no harmful side effects of Kratom. But the first usage of Kratom in women may be experimental. One has to be very cautious to adjust to Kratom.

Kratom may sometimes hinder the menstrual cycle in female users. Opiates have a high tendency to alter the period’s cycle. It makes the period come early than the due date but helps with period pains. Some women experience a disturbance in menstrual cycle by opiates, but many feel no change at all.

For menopause symptoms, Kratom works excellent. It helps to reduce the irritability of mood, hot flashes and night sweats. It brings no side effect for middle to older age women.

The very first experience of Kratom may be challenging for women. As per a female Kratom user, she started using Kratom for pain relief. She started her first dose by 9 am in the morning.

By evening, her body began to overheat, and she realized that she didn’t have any sufficient water all day. Once she drank water, she started feeling better. It suggests that Kratom may cause dehydration in initial experiences. Remember to hydrate your body when you switch to Kratom.


  • Do not use Kratom when you are pregnant or breastfeeding.
  • Do not use Kratom if you are under 18 years of age.
  • Do not combine Kratom with any hormonal supplements.
  • Do not combine Kratom with painkillers.
  • Do not use Kratom if you are on a regular medicine.
  • Do not use Kratom if you have a chronic disease, consult your doctor before using anything in this case.


Every Kratom user is different, and the body reactions towards Kratom will also be different. Woman’s body will show up best effects even on a smaller dose. This is not a bad deal. Overall, they are getting the same benefit for less quantity of Kratom.

In this way it reduces the risk of overdosing, thus ensures a safe Kratom experience. It is also budget friendly, and their stock of Kratom will last longer than men.

Jennifer Kurtz studied medicine at the New Jersey School of Medicine (Rutgers). She is passionate about developing her knowledge of Cannabis, Nootropics, Kratom, and nutritional supplements. In addition to attending medical webinars and conferences, she loves to write research-based articles for magazines, healthcare professionals, and medical agencies.