Alpha GPC is one of the most robust smart supplements that are useful in treating several brain problems, ranging from brain stroke to aging.

It is a natural water-soluble compound that is a product of phosphatidylcholine degradation.

It is also known as choline alfoscerate, choline alfoscerate, choline-glycerophosphate, L-alpha-glyceryl phosphorylcholine, and Glycerophosphocholine. It should not be confused with Choline, DMAE, and CDP-choline.

How is Alpha GPC produced?

Alpha GPC is produced on a commercial level through chemical or enzymatic deacylation process of phosphatidylcholine enriched by soybean phospholipids.

Chromatography then purifies it. It is also produced from purified sunflower lecithin and highly purified soy lecithin.

Mechanism of action of Alpha GPC

It includes choline that is necessary for optimal brain function, besides glycerol and phosphate.

These two elements work in sync with choline for the protection of cell membranes and their maintenance, thereby nourishing the nervous cells of the brain. This property is known as the neuroprotectant property of Alpha GPC.

According to research studies, alpha-GPC enhances memory and cognition.

It stimulated the release of GABA, a neurotransmitter responsible for producing calmness in the brain. This implies that it can also be used to treat anxiety and seizure disorders.

It boosts the cognitive recovery in patients with stroke. It is also believed to increase the levels of neurotransmitter acetylcholine because of which there is an increase in the secretion of human growth hormone (HGH).

It is an exceptional supplement because it can easily pass the Blood Brain Barrier. As an implication, you do not need to take it in copious quantities to bring about the desired physiological effect.

Alpha GPC is also believed to facilitate the responses on neurons to the respective neurotransmitters, thus enhancing communication between brain cells.

It also improves performance on psychometric tests. It helps in measuring intelligence, emotional reactions, and behavior, in healthy individuals as well as patients with Alzheimer’s disease.

Medicinal value of Alpha GPC

  1. Alzheimer’s disease

Alzheimer’s Disease is an unfortunate disease that leads to severe memory loss. Alpha GPC can be considered for the treatment of this disease.


  1. Stroke

According to an Italian study, alpha GPC proved to be helpful to patients with a stroke or transient ischemic attack.

The patients have injected the supplement for the first four weeks, later followed by 400 mg of the oral form thrice every day for five months.

It was noticed that their memory and behavioral function were significantly improved.


  1. Ageing

Alpha GPC intervention can counteract the age-dependent reduction of nerve cells in the hippocampus and cerebral cortex, thereby preventing senility.

Researchers concluded that Alpha GPC is highly effective in retarding the expression of changes taking place in the structure of the aging brain.

Apart from this, Alpha GPC enhanced the transduction of the nerve signal that is necessary for learning and cognition in young animals and maintained it in the older ones.


  1. Vascular dementia

Alpha GPC supplementation will be beneficial for patients who have mild to moderate vascular dementia. It leads to better cognition, memory, and acts as an antidepressant.

Vascular dementia

  1. Growth hormone releaser

According to a study, secretion of Growth Hormone reduces considerably as a person ages. The reason for this decrease is a rise in the release of hypothalamic somatostatin hormone that is inhibited by agonists of choline.

Another reason can be a decline in GHRH (Growth Hormone Releasing Hormone).

It was concluded in the study that the substance potentiated growth hormone secretion in elderly subjects. Because of an increase in the cholinergic tone, Alpha GPC is an important release of Growth Hormone.

Growth hormone releaser

  1. Anxiety and seizure disorders

Alpha GPC activates GABA, a calmness producing neurotransmitter. This indicates that it can be useful in anxiety and seizure disorders, as discussed earlier.


  1. Post-exertion recovery

Athletes who wish to perform better or build lean muscle mass can benefit a lot from Alpha GPC.

Additionally, it also helps to reach peak energy during the workout and recover instantly from the same. It is a valuable supplement for all the fitness freaks out there.

Post-exertion recovery

  1. Enhance mood and mental stamina

Alpha GPC is said to make the individual more vigilant about the surroundings, thereby enhancing alertness and concentration. It makes people more energetic and acts as a mood enhancer.

If you are feeling depressed, it is a great substance to pep up your mood. You get a better clarity of thought through this substance.

Mental Stamina

  1. Temporary amnesia

Healthy and young volunteers suffering from temporary chemical-induced amnesia can get their memory restored through Alpha GPC.

Temporary amnesia

  1. Choline source in Nootropic stacks

Alpha GPC can be paired with racetam supplements for optimal nootropic effect.

It generates sufficient choline for cognitive enhancement effects and can eliminate minor headaches that arise because of racetam side effects.

Nootropic stacks


Expert health professionals advise a dosage of 400 mg, taken thrice daily. It is available as tablets, capsules, and powders.

Injections can also be an option in certain cases.

As a nootropic, it can be used in the dose of 300-600 mg to start with and then the dose can be increased according to the benefits.

Make sure you take medicine under the supervision of an experienced physician.

Side effects of Alpha GPC

Noticeable side effects have not recorded after the usage of Alpha GPC. However, complaints like heartburn, insomnia, nausea, and headache have been encountered in less than 1% of the patients.

It can also lead to gastrointestinal distress, low blood pressure, and dizziness sometimes. These can be eliminated if take in a lesser amount.

Interactions with other drugs

Alpha GPC can interact with scopolamine, resulting in adverse effects. Both these medications should not be taken as a combination.


No known contraindications exist against the use of Alpha GPC. However, if you are hypertensive, you should take the advice of a medical professional before taking Alpha GPC.

Pregnant and nursing women should avoid taking it due to limited research proofs.

Some key facts to remember

Alpha GPC seems to be a safe drug that is suggested to enhance the cognitive power of people in the initial stages of cognitive deterioration because of circulatory disturbances or Alzheimer’s disease.

Notwithstanding that, Alpha GPC is of no value to healthy individuals. If studies are to be believed, the effectiveness of this substance majorly relies on its ability to increase acetylcholine levels in the brain.

As a result, it is quite dubious whether Alpha GPC will be of much value to healthy individuals. This is because acetylcholine levels are sufficient if there is no illness.

Storage of Alpha GPC

Storage of Alpha GPC is a key point to consider. It is reported to degrade when stored in the open for a long time. It is hygroscopic and imbibes moisture from the air around.

As a result, the powder gets converted into a gel.

Alpha GPC that is more than 99% pure will undergo this change in minutes, owing to which it should not be exposed to air.

Because of this hygroscopic property, Alpha GPC should be stored in such a way that it removes all air from the container.

Double bagging in plastic bags especially for chemicals and storing the excess inside the freezer are the methods that can be used.

Note that hygroscopy is not synonymous to degradation and it can still be used. The only challenge is that the substance cannot accurately weigh because it will be a mixture of powder plus water.


If you are suffering from stress disorders or mental disturbances, or anyone in your family has dementia, you can surely try out Alpha GPC as a medicine.

The effects of this medication are utterly miraculous and worth a try. You can vouch on this substance to enhance your mood and ensure a mental well-being.

Faisal Jamal leads the team at Restorm Scientific and believes in ethical medical marketing. He has helped many leading healthcare companies to develop a successful marketing strategy in a rapidly changing marketplace. He has a great passion for medical research and believes in providing evidence-based information on Cannabis, CBD, & Kratom.